Abstract Cryo-EM structural analysis reveals that ClC-7 binds to PI(5)P (phosphatidylinositol-5-phosphate), which locks the protein in its inactivated state. By contrast, PI(3,5)P2 (phosphatidylinositol-3,5-bisphosphate) did not bind and molecular dynamics (MD) simulations demonstrate indicate a preference of ClC-7 binding to PI(5)P over PI(3,5)P2. The data suggest that regulation of lysosomal ion homeostasis by ClC-7 is controlled by PI(5)P, revealing a molecular function of this enigmatic endo-lysosomal PIP. 

The dataset contains match-level data from the top-tier football leagues in England, France, Italy, and Spain during the seasons 2014/15–2021/22, including match dates, results, performance indicators, and betting odds.

This work revisits the K+-ion conducting K3−xSb1−xWxS4 (0 ≤ x ≤ 0.10) system and finds a more complex structural scenario than previously reported. K3SbS4 does not only crystallize in the reported  space group, but also in a structure best described in the  space group. Both polymorphs are found present at room temperature, whereas variable temperature synchrotron X-ray diffraction shows that only the  phase persists at elevated temperatures. Similarly, the substitution of Sb(+V) with W(+VI) stabilizes the high temperature  polymorph. K3SbS4 further shows similar diffusion pathways for both polymorphs. It matches the measured transport properties dominated by W(+VI) substitution increasing ionic conductivity up to 0.64 mS∙cm−1 at 298 K for nominal K2.92Sb0.92W0.08S4 with an activation energy of 0.29 eV. This work emphasizes the need for a complementary understanding of atomic arrangement and microstructure in potassium-ion conductors.

This data set is an output of the DFG-funded project "Prodatphil -- Science and Logic" (project number 537184692), a cooperation of the Center of Philosophy of Science and the Service Center for Digital Humanities of the university of Münster (principal investigator Stefan Heßbrüggen-Walter). The project started in July 2024 and is currently funded until July 2027. Please note that these are historical sources which may contain racist tropes or other content that discriminates against groups of people. Data are made available for research purposes and are not to be understood as propaganda or an endorsement of discriminatory practices. This corpus of texts on logic in English contains in sum 147 works, 44 books and 103 articles. Texts were written by 74 known authors and published between 1831 and 1923. Articles were published in 16 journals. All texts are in the public domain.The data set consists of two files:  `prodatphil_en_txt_0_3.zip` contains a README file, texts, metadata and a corpus description as HTML file and Jupyter notebook. In addition, `prodatphil_code_data_en_0_3.zip`  contains additional data and code used to produce the corpus. We provide code and additional data for documentary purposes only. The code would need additional corrections (e. g. regarding paths) in order to run reproducibly.

Data repository supporting:The search for highly conducting solid ionic conductors requires a deep understanding of the underlying crystal structure and local dynamic processes. Therefore, cationic and anionic substitutions are typically performed to monitor the resulting changes in the structure and ionic transport, ultimately drawing conclusions to find optimized Li+ conductors. Within a substitution series, the anionic framework is generally assumed to be non-changing. This study addresses the question whether the targeted introduction of extrinsic anion vacancies can be stabilized within the a Li+ argyrodite. Using diffraction and spectroscopic techniques, Monte Carlo simulations as well as density functional theory calculations, changes in crystal structure and ionic and electronic transport are monitored and the configurational stability is assessed. The structures with anion vacancies were found to have high formation energies, in agreement with the experimental observation. Instead, the phase formation of Li6+xPS5+xCl1−x is observed, showing a decrease in Li+ conductivity related to the anion ordering.

Solid electrolytes are central to the development of solid-state batteries. Beyond the search for further high-conductivity compositions, the synthesis pathway can shape the structures and transport properties of the resulting material. Two scalable precursor-mixing strategies, planetary ball milling and cutting mill mixing, are compared for the formation of chloride-rich argyrodite Li5.5PS4.5Cl1.5. In situ neutron powder diffraction tracks the reaction progress, complemented by ex situ neutron and X-ray powder diffraction, differential scanning calorimetry, and impedance spectroscopy. The argyrodite phase in both products converges to the same final composition, but the two routes follow different reaction trajectories: ball-milled precursors react at lower temperatures and shorter dwell times than cutting mill precursors, which require higher temperatures and longer times to reach comparable chloride contents. The chloride content within the argyrodite phase is identified as the principal compositional descriptor of the ionic conductivity across the reaction conditions studied here, and extended annealing beyond complete reaction leads to chloride loss and reduced transport. These insights transfer to a reproducible large-scale synthesis under ambient-pressure gas-flow conditions, linking in situ mechanistic understanding to the scalable preparation of solid electrolytes.

Der Siedlungskomplex von El Tuweina liegt im Zentrum der Bayuda-Wüste im Nordsudan im südlichen Einzugsbereich des oberen Wadi Abu Dom, auf etwa halber Strecke zwischen den modernen Städten Merowe und Atbara. Hier befindet sich ein zusammenhängender Komplex aus drei Baustrukturen, teils aus Stein- teils aus Lehmziegelmauern errichtet, die in den Jahren 2013 (bauhistorische Testsondagen) sowie 2017-2019 (flächige Ausgrabung) durch das Institut für Ägyptologie und Koptologie der Westfälischen Wilhelms-Universität (WWU) Münster ausgegraben wurden.Das Bauensemble datiert in die Spät-Meroitische Epoche (ca. 3. Jahrhundert n.Chr.); in dieser Zeit stellte die zentrale Bayuda einen peripheren Raum dieser vor allem im Niltal beheimateten Kultur dar. Architektur und übrige materielle Kultur weisen dabei, nach bisherigen Erkenntnissen, ein deutliches Maß an Eigenständigkeit auf. Die Ergebnisse des Survey-Projektes "Wadi Abu Dom Itinerary" (2009-2016) der WWU Münster weisen für den Bereich des oberen Wadi Abu Dom auf eine überwiegend pastorale Ökonomie mit enger Verzahnung von sesshaften und mobilen Lebens- und Wirtschaftskonzepten.Die Analyse des in den Jahren 2017 bis 2019 in El Tuweina geborgenen Fundmaterials soll diese generellen Annahmen über die Sozial- und Wirtschaftsgeschichte der zentralen Bayuda einer Überprüfung unterziehen, sowie den Siedlungskomplex von El Tuweina in die nähere und weitere Kulturlandschaft einordnen.Die Analyse der Keramik und der Kleinfunde aus El Tuweina dient vor allem der Beantwortung der Frage nach dem Ausmaß der kulturellen Anbindung der Kulturen der zentralen Bayuda an die damalige meroitische Leitkultur. Dies ermöglicht auch mittelbare Rückschlüsse auf den politisch-administrativen Einfluss der staatlichen Strukturen des meroitischen Reiches auf die dünn besiedelte Peripherie.Die Analyse botanischer und zoologischer Proben dient vor allem der Beantwortung der Frage nach der ökonomischen Grundlage der damaligen Bevölkerung. Von Bedeutung ist dabei vor allem die Frage, ob sich der bisherige Eindruck einer vor allem pastoral und mobil geprägten Subsistenzwirtschaft mit nur geringer Abhängigkeit vom Niltal verstetigt, und ob die Bevölkerung der zentralen Bayuda während der meroitischen Epoche in die so genannten "cattle complex"-Kulturen einzuordnen ist (was sozio-kulturelle Kontinuitäten zu heutigen Nilotisch- bzw. Fulani-sprachigen Gemeinschaften implizieren würde).

Scripts and data for the generation of results leading to the conclusion in the ChI-SOM publication. This includes Generation and analysis of synthetic and chemiformatical dimensionality reduction problem sets using t-SNE, UMAP and emergent SOM (ESOM) Runtime and memory benchmark of the ChI-SOM implementation Scripts for the generation and analysis of a 5.7m neuron ChEMBL33 ESOM

Objectives and methods: Postural instability is common among children with ADHD. Research on the effects of psychostimulant medication on postural control outcomes in ADHD is limited, and findings are mixed. By assessing static and dynamic balance, this multi-level approach attempts to offer a more comprehensive understanding of postural control in children with differing neurological and medicative status. Results: Children with ADHD did not sway more than typically developing peers but exhibited subtle differences in sway organization that depended on the specific nonlinear parameter (differences in fractal dimension, but not in entropy measures) and balance task (differences in static but not in dynamic balance). Group alterations occurred primarily at the level of biomechanical implementation rather than in the observable sway behavior. While both ADHD groups presented stiffer and more restrained hip-based control during static balance, the medicated group showed markedly higher torque amplitude and variation around the hip and upper body joint group during dynamic balance. Conclusion: The present findings demonstrate that comparable balance performance can be achieved through fundamentally different biomechanical stabilization strategies. While neurotypical children show rich complexity that is well-adjusted to task demands, ADHD patients are more rigid in their postural control. This reverses with increasing balance demands; medicated ADHD patients achieve stabilization with highly variable proximal efforts, which is more likely to display over-recruitment than efficient, flexible postural adjustment. The dissociation between kinematic and kinetic measures emphasizes the importance of assessing not only the outcome of postural control, but also the mechanisms by which it is achieved.

This dataset contains basalt and peridotite geochemical compositions, namely major and trace elements, from the Gakkel Ridge and Lena Trough. Dataset S1. Major and trace element compositions of basalts analyzed in this study. Dataset S2. Major and trace element bulk and mineral compositions of peridotites analyzed in this study.  Dataset S3. Basalt geochemistry. Compilation of newly acquired and previously published data as described in Section 3.1 in the main text. Magnetic anomaly intensities are extracted from GeoMapApp v3.7.4 (https://www.geomapapp.org) using the EMAG2 (2-arc-minute resolution, 2013) dataset (Maus et al., 2009). Dataset S4. Basalt geochemical dataset based on Dataset S3, with values averaged per sample. Dataset S5. Peridotite geochemistry. Compilation of newly acquired and previously published data as described in Sections 3.1 and 3.2 in the main text. Magnetic anomaly intensities are extracted from GeoMapApp v3.7.4 (https://www.geomapapp.org) using the EMAG2 (2-arc-minute resolution, 2013) dataset (Maus et al., 2009). See table note for explanation of additional parameters. Dataset S6. Peridotite geochemical dataset based on Dataset S5, with values averaged per sample.